Tympanometry Comparison of Diabetic Type I and Diabetic Type II Rats

Hearing impairment affects over two-thirds of adults with diabetes. We investigated whether rat models type 1 and 11 diabetes display impaired auditory function. Tympanometry measurements were conducted in Sprague-Dawley rats (control, n = 20), streptozotocin-induced I diabetic (n 20) at 42 - 56 days old; Zucker (Hos: ZFDM-Lean (fa/+, Type 2 Diabetic (ZFDM ZFDM-fa/fa); 20)), 90 old. All male. Control animals had normal A tympanograms. Tweny one (75%) the tympanic membranes group produced abnormal tympanograms: 46% B, 28% no peak found, 1% C. The ear canal lower left mice (0.19 ± 0.07) higher for II (0.23 0.15 ml) compared to controls 0.39 0.14 (0.2 0.12 respectively (P < 0.0001). compliances right (0.18 0.05 control (0.28 0.19 0.49 0.0001) respectively. In conclusion, exhibited tympanograms a highly functional middle system. mostly B less compliant Compliance was reduced control. Future studies should utilise histological methods alongside tympanometry. Sections could be used analyze ossicle size confirm differences. This information would useful avenues treatment options hearing loss